Diazepam may well interfere with metabolism of substrates for CYP2C19 and CYP3A4 leading to a potential drug-drug interactiondiazepam will increase the amount or outcome of lemborexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Reduce nightly dose of lemborexant suggested if coadministered with weak CY